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目的 探讨视神经脊髓炎谱系疾病（NMOSD）患者脑深部灰质核团氧提取分数（OEF）变化及其与认知损害的关系。方法 选取NMOSD患者32例（观察组）、体检健康的志愿者55例（对照组），通过定量磁化率成像（QSM）和定量血氧水平依赖成像（qBOLD）评估脑深部灰质核团壳核（Pu）、尾状核（Ca）、伏隔核（NAc）、红核（RN）、丘脑下核（STN）、苍白球外侧部（GPe）、苍白球内侧部（GPi）、腹侧苍白球（VeP）等感兴趣区的OEF。通过神经心理测验评估认知功能。采用Pearson偏相关分析法分析NMOSD患者脑深部灰质核团OEF与认知损害的关系。结果 两组蒙特利尔认知评估量表（MoCA）评分、听觉词语学习测验评分、符号数字转换测试评分、连线测验A(TMT-A)比较差异均有统计学意义（P均<0.05）。观察组脑深部灰质核团Pu、Ca、NAc、GPe、GPi、RN、VeP、STN的OEF均显著高于对照组（P均<0.05）。Pearson偏相关分析显示，NMOSD患者脑深部灰质核团GPe、GPi、VeP、STN的OEF与TMT-A均呈正相关（r分别为0.601、0.615、0.601、0.512,P均<0.05,FDR校正），脑深部灰质核团GPe、GPi、VeP、STN的OEF与MoCA评分均呈负相关（r分别为-0.428、-0.441、-0.498、-0.499,P均<0.05,FDR校正）。结论 NMOSD患者脑深部灰质核团OEF普遍升高，并且OEF升高与特定认知域功能损害显著相关。
Abstract：Objective To investigate the alterations in oxygen extraction fraction(OEF) within deep gray matter nuclei and their correlation with cognitive impairment in patients with neuromyelitis optica spectrum disorder(NMOSD). Methods 32 NMOSD patients and 55 healthy controls(HCs) were enrolled. OEF values were quantified in multiple DGM nuclei-including the putamen(Pu), caudate nucleus(Ca), nucleus accumbens(NAc), red nucleus(RN), subthalamic nucleus(STN), external globus pallidus(GPe), internal globus pallidus(GPi), and ventral pallidum(VeP) using a joint quantitative susceptibility mapping(QSM) and quantitative blood oxygen level-dependent(qBOLD) imaging approach(QQ model). Cognitive function was assessed through standardized neuropsychological tests. Pearson partial correlation analysis was performed to examine the associations between OEF values in DGM nuclei and cognitive performance in NMOSD patients. Results There were statistically significant differences in the scores of the Montreal Cognitive Assessment Scale(MoCA), Auditory Verbal Learning Test, Symbol Digit Modalities Test, and Trail Making Test A(TMT-A) between the two groups(all P < 0.05). The OEF of the deep brain gray matter nuclei Pu, Ca, NAc, GPe, GPi, RN, VeP, and STN in the observation group was significantly higher than that in the control group(all P < 0.05). The partial correlation analysis showed that the OEF of the deep brain gray matter nuclei GPe, GPi, VeP, and STN in NMOSD patients was positively correlated with TMT-A(r = 0.601, 0.615, 0.601, 0.512, all P < 0.05, FDR correction), and the OEF of the deep brain gray matter nuclei GPe, GPi, VeP, and STN was negatively correlated with the MoCA scores(r =-0.428,-0.441,-0.498,-0.499, all P < 0.05, FDR correction). Conclusion The OEF values in the deep gray matter nuclei of the brain of patients with NMOSD were generally elevated, and it was found that the widespread increase in OEF was significantly correlated with specific cognitive domain impairments.
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基本信息:
DOI：10.20258/j.cnki.1006-9011.2026.03.001
中图分类号:R744.52;R445.2
引用信息:
[1]张文静,李茜,毕彦菲,等.NMOSD患者脑深部灰质核团OEF变化及其与认知损害的关系[J].医学影像学杂志,2026,36(03):1-6.DOI:10.20258/j.cnki.1006-9011.2026.03.001.
基金信息:
国家自然科学基金资助项目（编号：81601479）; 山东省自然科学基金资助项目（编号：ZR2025MS1359、ZR2025MS1482）; 山东省泰山学者建设工程（编号：tstp20240525）; 山东省博士后创新项目（编号：SDCX-ZG-202400047）
2026-03-30
2026-03-30