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目的 探讨磁共振灌注成像(magnetic resonance perfusion imaging, MR-PWI)检查对无症状神经梅毒进行早期诊断的临床价值。方法 选取168例无症状神经梅毒患者(观察组),另选取同期30例健康者(对照组),均行MR-PWI检查,测量局部脑血流量(regional cerebral blood flow,rGBF)、局部脑血容量(regional cerebral blood volume,rCBV)、平均通过时间(mean transit time, MTT)、达峰时间(time to peak, TTP)并展开分析。结果 两组额叶(双侧)、顶叶(双侧)、额叶海马区(双侧)、基底节区(双侧)的rGBF比较,差异无统计学意义(P>0.05);观察组额叶(双侧)、顶叶(双侧)、额叶海马区(双侧)、基底节区(双侧)的rCBV、MTT、TTP均高于对照组,差异有统计学意义(P<0.05);在无症状神经梅毒诊断中MRPWI检查的准确率为96.97%,特异度为93.33%,灵敏度为97.62%;治疗后,观察组各区域rGBF比治疗前升高,rCBV、MTT、TTP比治疗前降低,差异有统计学意义(P<0.05)。结论 在无症状神经梅毒的早期诊断中,MR-PWI检查有良好应用价值,并可应用于疗效评估中。
Abstract:Objective To investigate the clinical value of magnetic resonance perfusion imaging(MR-PWI) in the early diagnosis of asymptomatic neurosyphilis. Methods 168 patients with asymptomatic neurosyphilis admitted to our hospital were selected as the experimental group, another 30 healthy individuals admitted to our hospital during the same period were selected as the control group, the MR-PWI examination was performed in all cases, and the parameters in terms of local cerebral blood flow(rGBF), local cerebral blood volume(rCBV), mean transit time(MTT), and peak time(TTP) were obtained for analysis. Results The rGBF of frontal lobe(bilateral), parietal lobe(bilateral), frontal hippocampus(bilateral) and basal ganglia(bilateral) were compared between two groups(P>0.05). In the experimental group, the rCBV, MTT and TTP in the frontal(bilateral), parietal(bilateral), hippocampal(bilateral) and basal ganglia(bilateral) regions were higher than those in the control group(P< 0.05). In the diagnosis of asymptomatic neurosyphilis, the accuracy of MR-PWI was 96.97%, the specificity was 93.33%, and the sensitivity was 97.62%. After treatment, the rGBF in each area of the experimental group was higher than that before treatment, while, the rCBV, MTT and TTP were lower than those before treatment(P<0.05). Conclusion In the early diagnosis of asymptomatic neurosyphilis, MR-PWI examination has good application value, which can be used in the evaluation of efficacy.
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基本信息:
DOI:10.20258/j.cnki.1006-9011.2025.08.001
中图分类号:R759.13;R445.2
引用信息:
[1]赵瑞云,解玉文.MR-PWI检查在无症状神经梅毒早期诊断中的临床价值[J].医学影像学杂志,2025,35(08):1-4+9.DOI:10.20258/j.cnki.1006-9011.2025.08.001.
基金信息:
中国红十字会基金项目(编号:XM_HR_ICON_2021_05)